杨槟源  博士 教授

E-mail：yangbingyuan@ouc.edu.cn

教育背景：2013年本科毕业于西南大学水产养殖专业，同年考入中国科学院水生生物研究所，18年获得博士学位。随后，先后在美国范德堡大学(Vanderbilt University)（2018-2022）与香港城市大学（City University of HongKong）（2023-2024）从事博士后研究工作。2024年起任中国海洋大学教授至今。入选中国海洋大学“青年英才工程”第一层次。

主要研究方向及成果：

主要从事鱼类营养学；鱼类营养代谢及内分泌调控。

主要学术成果：

1. Yulong Gong*, Bingyuan Yang*, Dingdong Zhang, Zihan Tang, Katie C Coates, Walter A Siv, Ravi S Patel, Matthew Shou, Katelyn Sellick, Brittney A Covington, Liu Yang, E Danielle Dean, Alvin C Powers, and Wenbiao Chen. Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between mTORC1 and CaSR-Gq signaling pathways. Nature Communications. (2023) 14: 235.

2. Bingyuan Yang*, Lisette A. Maddison*, Karolina E. Zaborska, Chunhua Dai, Linlin Yin, Zihan Tang, Liqing Zang, David A. Jacobson, Alvin C. Powers, Wenbiao Chen. RIPK3-mediated inflammation is a conserved β cell response to ER stress [J]. Science Advances 2020, 6: eabd7272.

3. Bingyuan Yang, Liu Yang, Yueyang Wang, Lisette A. Maddison, Zihan Tang, Sander Haigh, Yulong Gong, Yue Zhang, Brittney A Covington, Karin J. Bosma, Xin Tong, Patrick Page-McCaw, Maureen Gannon, Qing Deng, Wenbiao Chen. Macrophages and neutrophils mediate overnutrition-induced β cell failure [J]. Cell Reports. 2022. 40(8): 111255.

4. Bingyuan Yang*, Gang Zhai*, Yulong Gong, Jingzhi Su, Dong Han, Zhan Yin, Shouqi Xie. Depletion of insulin receptors leads to β-cell hyperplasia in zebrafish [J]. Science Bulletin 2017, 62: 486-492.

5. Bingyuan Yang, Yue Zhang, Liu Yang and Wenbiao Chen*. Optimized protocol for live imaging of overnutrition-elicited interactions between immune cells and β cells in Zebrafish. STAR protocols.2022. 4(1).

6. Bingyuan Yang*, Gang Zhai*, Yulong Gong*, Jingzhi Su, Xuyan Peng, Guohui Shang, Dong Han, Junyan Jin, Haokun Liu, Zhenyu Du, Zhan Yin, and Shouqi Xie. Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish [J]. American Journal of Physiology Endocrinology & Metabolism 2018, 315: E38-E51.

7. Bingyuan Yang, Brittney A. Covington and Wenbiao Chen. In vivo generation and regeneration of β cells in zebrafish [J]. Cell Regeneration. 2020 9(1):9.

8. Hadil El-Sammak, Bingyuan Yang, Stefan Guenther, Wenbiao Chen, Rubén Marín-Juez, Didier Y.R. Stainier. A-Vegfc regulates revascularization via the Emilin2a-Cxcl8a axis during cardiac regeneration in zebrafish. Circulation Research 2022, 130: 1014-1029.

9.Yulong Liu, Gang Zhai, Jingzhi Su, Yulong Gong, Bingyuan Yang,Qisheng Lu, Longwei Xi, Yutong Zheng, Jingyue Cao, Haokun Liu, Junyan Jin, Zhimin Zhang, Yunxia Yang, Xiaoming Zhu, Zhongwei Wang, Gaorui Gong,Jie Mei, Zhan Yin, Rodolphe E. Gozlan, Shouqi Xie, and Dong Han.The Chinese longsnout catfish genome provides novel insights into the feeding preference andcorresponding metabolic strategy of carnivores [J].Genome Research,2024 Aug 20;34(7):981-996

10. Liu Yang, Margret A. Fye, Bingyuan Yang, Zihan Tang, Yue Zhang, Sander Haigh, Brittney A. Covington, Kai Bracey, Justin W. Taraska , Irina Kaverina, Shen Qu, Wenbiao Chen. Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion [J]. Molecular Metabolism 2022, 63: 101541.